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Annals of the New York Academy of Sciences
REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS
Volume 961 published June 2002

Editors:
Jean D. Sipe
Christine A. Kelley
Loré Anne McNichol


[Index by Author]

Contents:

       Reparative Medicine: Growing Tissues and Organs
       Part I. Cells for Repair: A. Cell Regeneration
       Part I. Cells for Repair: B. Genetic Approaches to Tissue Repair
       Part II. Bioscaffolds for Tissue Repair
       Part III. Molecular Signaling
       Part IV. Tissue Generation: A. Functional Considerations in the Design of Engineered Tissue
       Part IV. Tissue Generation: B. Bioreactors and Bioprocessing
       Part IV. Tissue Generation: C. Vascular Assembly in Engineered and Natural Tissues
       Part IV. Tissue Generation: D. Storage and Translational Issues
       Part V. Engineered Tissues in the Host: A. In Vivo Remodeling
       Part V. Engineered Tissues in the Host: B. Immune Response to Engineered Tissues and Cells

 
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JEAN D. SIPE, CHRISTINE A. KELLEY, and LORÉ ANNE McNICOL
Preface: Reparative Medicine: Growing Tissues and Organs
Ann NY Acad Sci 2002 961: xiii. [Full Text]  

Reparative Medicine: Growing Tissues and Organs:

JEAN D. SIPE
Tissue Engineering and Reparative Medicine
Ann NY Acad Sci 2002 961: 1-9. [Abstract] [Full Text]  

W. T. GODBEY and A. ATALA
In Vitro Systems for Tissue Engineering
Ann NY Acad Sci 2002 961: 10-26. [Abstract] [Full Text]  

Part I. Cells for Repair: A. Cell Regeneration:

NANCY L. PARENTEAU and JANET HARDIN YOUNG
The Use of Cells in Reparative Medicine
Ann NY Acad Sci 2002 961: 27-39. [Abstract] [Full Text]  

DENISE L. FAUSTMAN
Reversal of Established Autoimmune Diabetes by in Situ ß-Cell Regeneration
Ann NY Acad Sci 2002 961: 40. [Full Text]  

SEUNG K. KIM
Pancreatic Islet Cell Replacement: Successes and Opportunities
Ann NY Acad Sci 2002 961: 41-43. [Full Text]  

RON McKAY
Building Animals from Stem Cells
Ann NY Acad Sci 2002 961: 44. [Full Text]  

DENISE L. FAUSTMAN, ROGER L. PEDERSEN, SEUNG K. KIM, IHOR R. LEMISCHKA, RONALD D. McKAY, and DENISE L. FAUSTMAN
Cells for Repair: Breakout Session Summary
Ann NY Acad Sci 2002 961: 45-47. [Full Text]  

Part I. Cells for Repair: B. Genetic Approaches to Tissue Repair:

JEFFREY BONADIO and MICHAEL L. CUNNINGHAM
Genetic Approaches to Craniofacial Tissue Repair
Ann NY Acad Sci 2002 961: 48-57. [Abstract] [Full Text]  

JEFFREY BONADIO
Genetic Approaches to Tissue Repair
Ann NY Acad Sci 2002 961: 58-60. [Full Text]  

SAVIO L. C. WOO
Gene Transfer in Tissue Regeneration and Reparative Medicine
Ann NY Acad Sci 2002 961: 61-62. [Full Text]  

KATHERINE HIGH
Gene-Based Approaches to the Treatment of Hemophilia
Ann NY Acad Sci 2002 961: 63-64. [Full Text]  

STEVEN C. GHIVIZZANI
Genetic Approaches to the Repair of Connective Tissues
Ann NY Acad Sci 2002 961: 65-67. [Full Text]  

DAVID V. SCHAFFER
Genetic Approaches to Tissue Repair
Ann NY Acad Sci 2002 961: 68-70. [Full Text]  

JEFFREY BONADIO, SAVIO L.C. WOO, KATHERINE HIGH, STEVEN C. GHIVIZZANI, DAVID SCHAFFER, and JEFFREY BONADIO
Genetic Approaches to Tissue Engineering: Breakout Session Summary
Ann NY Acad Sci 2002 961: 71-72. [Full Text]  

ANNA M. OSYCZKA, ULRICH NÖTH, KEITH G. DANIELSON, and ROCKY S. TUAN
Different Osteochondral Potential of Clonal Cell Lines Derived from Adult Human Trabecular Bone
Ann NY Acad Sci 2002 961: 73-77. [Abstract] [Full Text]  

Y. LU, J. SHANSKY, M. DEL TATTO, P. FERLAND, S. MCGUIRE, J. MARSZALKOWSKI, M. MAISH, R. HOPKINS, X. WANG, P. KOSNIK, M. NACKMAN, A. LEE, B. CRESWICK, and H. VANDENBURGH
Therapeutic Potential of Implanted Tissue-Engineered Bioartificial Muscles Delivering Recombinant Proteins to the Sheep Heart
Ann NY Acad Sci 2002 961: 78-82. [Abstract] [Full Text]  

Part II. Bioscaffolds for Tissue Repair:

LINDA G. GRIFFITH
Emerging Design Principles in Biomaterials and Scaffolds for Tissue Engineering
Ann NY Acad Sci 2002 961: 83-95. [Abstract] [Full Text]  

ELLIO L. CHAIKOF, HOWARD MATTHEW, JOACHIM KOHN, ANTONIO G. MIKOS, GLENN D. PRESTWICH, and CHRISTOPHER M. YIP
Biomaterials and Scaffolds in Reparative Medicine
Ann NY Acad Sci 2002 961: 96-105. [Abstract] [Full Text]  

GLENN D. PRESTWICH and HOWARD MATTHEW
Hybrid, Composite, and Complex Biomaterials
Ann NY Acad Sci 2002 961: 106-108. [Full Text]  

CHRISTOPHER YIP
Biomaterials in Reparative Medicine: Biorelevant Structure-Property Analysis
Ann NY Acad Sci 2002 961: 109-111. [Full Text]  

ELLIOT CHAIKOF, HOWARD MATTHEW, JOACHIM KOHN, GLENN D. PRESTWICH, ANTONIO MIKOS, CHRISTOPHER YIP, and ELLIOT CHAIKOF
Bioscaffolds for Tissue Repair: Breakout Session Summary
Ann NY Acad Sci 2002 961: 112-113. [Full Text]  

T.-M. G. CHU, S. J. HOLLISTER, J. W. HALLORAN, S. E. FEINBERG, and D. G. ORTON
Manufacturing and Characterization of 3-D Hydroxyapatite Bone Tissue Engineering Scaffolds
Ann NY Acad Sci 2002 961: 114-117. [Abstract] [Full Text]  

J. H. ELISSEEFF, A. LEE, H. K. KLEINMAN, and Y. YAMADA
Biological Response of Chondrocytes to Hydrogels
Ann NY Acad Sci 2002 961: 118-122. [Abstract] [Full Text]  

J. GLOWACKI, K. E. YATES, S. WARDEN, F. ALLEMANN, G. PERETTI, D. STRONGIN, R. MacLEAN, and D. ZALESKE
Engineering a Biological Joint
Ann NY Acad Sci 2002 961: 123-125. [Full Text]  

HONG WEI OUYANG, JAMES C.H. GOH, XIU MEI MO, SWEE HIN TEOH, and ENG HIN LEE
The Efficacy of Bone Marrow Stromal Cell-Seeded Knitted PLGA Fiber Scaffold for Achilles Tendon Repair
Ann NY Acad Sci 2002 961: 126-129. [Full Text]  

CHERYL L. STABLER, ATHANASSIOS SAMBANIS, and IOANNIS CONSTANTINIDIS
Effects of Alginate Composition on the Growth and Overall Metabolic Activity of ßTC3 Cells
Ann NY Acad Sci 2002 961: 130-133. [Full Text]  

E. J. CATERSON, W. J. LI, L. J. NESTI, T. ALBERT, K. DANIELSON, and R. S. TUAN
Polymer/Alginate Amalgam for Cartilage- Tissue Engineering
Ann NY Acad Sci 2002 961: 134-138. [Abstract] [Full Text]  

HERBERT P. JENNISSEN
Accelerated and Improved Osteointegration of Implants Biocoated with Bone Morphogenetic Protein 2 (BMP-2)
Ann NY Acad Sci 2002 961: 139-142. [Abstract] [Full Text]  

Part III. Molecular Signaling:

DONALD P. BOTTARO, ANDREA LIEBMANN-VINSON, and MOHAMMAD A. HEIDARAN
Molecular Signaling in Bioengineered Tissue Microenvironments
Ann NY Acad Sci 2002 961: 143-153. [Abstract] [Full Text]  

CAROLINE DAMSKY
Cell-Cell and Cell-Extracellular Matrix Adhesion Receptors
Ann NY Acad Sci 2002 961: 154-155. [Full Text]  

MOHAMMAD A. HEIDARAN
Convergence of Molecular Signaling and Tissue Engineering
Ann NY Acad Sci 2002 961: 156-157. [Full Text]  

DONALD P. BOTTARO
The Role of Extracellular Matrix Heparan Sulfate Glycosaminoglycan in the Activation of Growth Factor Signaling Pathways
Ann NY Acad Sci 2002 961: 158. [Full Text]  

KATHRYN L. CROSSIN
Cell Adhesion Molecules Activate Signaling Networks That Influence Proliferation, Gene Expression, and Differentiation
Ann NY Acad Sci 2002 961: 159-160. [Full Text]  

PATRICIA DUCY
Molecular Signaling
Ann NY Acad Sci 2002 961: 161. [Full Text]  

DONALD INGBER
Mechanical Signaling
Ann NY Acad Sci 2002 961: 162-163. [Full Text]  

CAROLINE DAMSKY, MOHAMMAD HEIDARAN, DONALD BOTTARO, KATHRYN CROSSIN, PATRICIA DUCY, and DONALD INGBER
Molecular Signaling: Breakout Session Summary
Ann NY Acad Sci 2002 961: 164-167. [Full Text]  

TERRI L. GILBERT, NICOLE GRIFFIN, JOHN MOFFETT, MARY C. RITZ, and FRANK R. GEORGE
The Provant® Wound Closure System Induces Activation of p44/42 MAP Kinase in Normal Cultured Human Fibroblasts
Ann NY Acad Sci 2002 961: 168-171. [Full Text]  

R. TULI, M. R. SEGHATOLESLAMI, S. TULI, M. S. HOWARD, K. G. DANIELSON, and R. S. TUAN
p38 MAP Kinase Regulation of AP-2 Binding in TGF-ß1-Stimulated Chondrogenesis of Human Trabecular Bone-Derived Cells
Ann NY Acad Sci 2002 961: 172-177. [Abstract] [Full Text]  

LEON J. NESTI, E. J. CATERSON, MARK WANG, RICHARD CHANG, FELIX CHAPOVSKY, JAN B. HOEK, and ROCKY S. TUAN
TGF-ß1-Stimulated Osteoblasts Require Intracellular Calcium Signaling for Enhanced {alpha}5 Integrin Expression
Ann NY Acad Sci 2002 961: 178-182. [Abstract] [Full Text]  

Part IV. Tissue Generation: A. Functional Considerations in the Design of Engineered Tissue:

STEVE A. GOLDSTEIN
Tissue Engineering: Functional Assessment and Clinical Outcome
Ann NY Acad Sci 2002 961: 183-192. [Abstract] [Full Text]  

Farshid Guilak
Functional Tissue Engineering: The Role of Biomechanics in Reparative Medicine
Ann NY Acad Sci 2002 961: 193-195. [Full Text]  

RAVI KAPUR
Fluorescence Imaging and Engineered Biosensors: Functional and Activity-Based Sensing Using High Content Screening
Ann NY Acad Sci 2002 961: 196-197. [Full Text]  

MICHAEL V. SEFTON
Functional Considerations in Tissue-Engineering Whole Organs
Ann NY Acad Sci 2002 961: 198-200. [Full Text]  

HERMAN H. VANDENBURGH
Functional Assessment and Tissue Design of Skeletal Muscle
Ann NY Acad Sci 2002 961: 201-202. [Full Text]  

ALAN P. KORETSKY
Functional Assessment of Tissues with Magnetic Resonance Imaging
Ann NY Acad Sci 2002 961: 203-205. [Full Text]  

REGIS J. O'KEEFE
Determination of Responsiveness in Biological Systems Is Dependent on Highly Sensitive Quantitative Measures
Ann NY Acad Sci 2002 961: 206. [Full Text]  

FARSHID GUILAK, RAVI KAPUR, MICHAEL V. SEFTON, HERMAN H. VANDENBURGH, ALAN P. KORETSKY, ANDRES KRIETE, REGIS J. O'KEEFE, and FARSHID GUILAK
Functional Assessment of Engineered Tissues and Elements of Tissue Design: Breakout Session Summary
Ann NY Acad Sci 2002 961: 207-209. [Full Text]  

Part IV. Tissue Generation: B. Bioreactors and Bioprocessing:

ANTHONY RATCLIFFE and LAURA E. NIKLASON
Bioreactors and Bioprocessing for Tissue Engineering
Ann NY Acad Sci 2002 961: 210-215. [Abstract] [Full Text]  

KYUNG A. KANG
Tissue Engineering as a Subdivision of Bioprocess Engineering: Reparative Tissue Engineering as a Subspecialty of Tissue Engineering
Ann NY Acad Sci 2002 961: 216-219. [Full Text]  

LAURA E. NIKLASON, ANTHONY RATCLIFFE, KELVIN BROCKBANK, DUANE F. BRULEY, and KYUNG A. KANG
Bioreactors and Bioprocessing: Breakout Session Summary
Ann NY Acad Sci 2002 961: 220-222. [Full Text]  

Part IV. Tissue Generation: C. Vascular Assembly in Engineered and Natural Tissues:

KAREN K. HIRSCHI, THOMAS C. SKALAK, SHAYN M. PEIRCE, and CHARLES D. LITTLE
Vascular Assembly in Natural and Engineered Tissues
Ann NY Acad Sci 2002 961: 223-242. [Abstract] [Full Text]  

THOMAS C. SKALAK
In Vivo and in Silico Approaches for Analysis and Design of Multisignal, Multicomponent Assembly Processes in Vascular Systems
Ann NY Acad Sci 2002 961: 243-245. [Full Text]  

LARRY V. McINTIRE
Vascular Assembly in Engineered and Natural Tissues
Ann NY Acad Sci 2002 961: 246-248. [Full Text]  

MARK J. POST
Angiogenesis: Initiation and Maintenance
Ann NY Acad Sci 2002 961: 249-250. [Full Text]  

ROBERT T. TRANQUILLO
The Tissue-Engineered Small-Diameter Artery
Ann NY Acad Sci 2002 961: 251-254. [Full Text]  

THOMAS C. SKALAK, CHARLES D. LITTLE, LARRY V. McINTIRE, KAREN K. HIRSCHI, ROBERT T. TRANQUILLO, MARK POST, and JOHN RANIERI
Vascular Assembly in Engineered and Natural Tissues: Breakout Session Summary
Ann NY Acad Sci 2002 961: 255-257. [Full Text]  

Part IV. Tissue Generation: D. Storage and Translational Issues:

MEHMET TONER and JEFFERY KOCSIS
Storage and Translational Issues in Reparative Medicine
Ann NY Acad Sci 2002 961: 258-262. [Full Text]  

DOUGLAS K. ANDERSON
Neural Tissue Transplantation in Syringomyelia: Feasibility and Safety
Ann NY Acad Sci 2002 961: 263-264. [Full Text]  

KELVIN G.M. BROCKBANK
Stabilization of Tissue-Engineered Products for Transportation and Extended Shelf-Life
Ann NY Acad Sci 2002 961: 265-267. [Full Text]  

L. GERMAIN, F. GOULET, V. MOULIN, F. BERTHOD, and F. A. AUGER
Engineering Human Tissues for in Vivo Applications
Ann NY Acad Sci 2002 961: 268-270. [Full Text]  

RAPHAEL C. LEE
Cytoprotection by Stabilization of Cell Membranes
Ann NY Acad Sci 2002 961: 271-275. [Full Text]  

JEFFREY D. KOCSIS, MEHMET TONER, DOUGLAS K. ANDERSON, KELVIN BROCKBANK, LUCIE GERMAIN, RAPHAEL C. LEE, and JEFFREY D. KOCSIS
Storage and Translational Issues in Reparative Medicine: Breakout Session Summary
Ann NY Acad Sci 2002 961: 276-278. [Full Text]  

PAUL I. MUSEY, SOBRASUA M. IBIM, and NIRANJAN K. TALUKDER
Development of Artificial Blood Vessels: Seeding and Proliferation Characteristics of Endothelial and Smooth Muscle Cells on Biodegradable Membranes
Ann NY Acad Sci 2002 961: 279-283. [Full Text]  

WOLFF M. KIRSCH, YONG HUA ZHU, ROBERT STECKEL, WALDO CONCEPCION, KERBY OBERG, LENNART ANTON, and NORMAN PECKHAM
In Vivo Remodeling of Surgically Constructed Vascular Anastomoses: Nonpenetrating, Arcuate-Legged Clips versus Standard Suture
Ann NY Acad Sci 2002 961: 284-287. [Full Text]  

IN KAP KO and HIROO IWATA
Simple Method for Increasing Cell-Attachment Ability of Biodegradable Polyester
Ann NY Acad Sci 2002 961: 288-291. [Full Text]  

JOSEF H. WISSLER
Engineering of Capillary Patterns in Muscle by a Nonmitogenic Copper-Ribonucleoprotein Angiomorphogen [Angiotropin CuRNP Ribokine]
Ann NY Acad Sci 2002 961: 292-297. [Full Text]  

IOANNIS CONSTANTINIDIS, CHERYL L. STABLER, ROBERT LONG, Jr., and ATHANASSIOS SAMBANIS
Noninvasive Monitoring of a Retrievable Bioartificial Pancreas in Vivo
Ann NY Acad Sci 2002 961: 298-301. [Full Text]  

Part V. Engineered Tissues in the Host: A. In Vivo Remodeling:

STEPHEN F. BADYLAK
In Vivo Studies to Evaluate Tissue Engineering Techniques
Ann NY Acad Sci 2002 961: 302-304. [Full Text]  

MARKUS GROMPE
Transition of Stem Cells to Therapeutically Functional Tissue-Specific Cells
Ann NY Acad Sci 2002 961: 305-306. [Full Text]  

ARNOLD I. CAPLAN
In Vivo Remodeling
Ann NY Acad Sci 2002 961: 307-308. [Full Text]  

HOWARD P. GREISLER
Regulated in Vivo Remodeling
Ann NY Acad Sci 2002 961: 309-311. [Full Text]  

ROBERT E. GULDBERG
Consideration of Mechanical Factors
Ann NY Acad Sci 2002 961: 312-314. [Full Text]  

DORIS A. TAYLOR
Is in Vivo Remodeling Necessary or Sufficient for Cellular Repair of the Heart?
Ann NY Acad Sci 2002 961: 315-318. [Full Text]  

STEPHEN F. BADYLAK, MARKUS GROMPE, ARNOLD I. CAPLAN, HOWARD P. GREISLER, ROBERT E. GULDBERG, DORIS A. TAYLOR, and STEPHEN F. BADYLAK
In Vivo Remodeling: Breakout Session Summary
Ann NY Acad Sci 2002 961: 319-322. [Full Text]  

Part V. Engineered Tissues in the Host: B. Immune Response to Engineered Tissues and Cells:

DAVID M. HARLAN, CHRISTOPHER L. KARP, POLLY MATZINGER, DAVID H. MUNN, RICHARD M. RANSOHOFF, and DENNIS W. METZGER
Immunological Concerns with Bioengineering Approaches
Ann NY Acad Sci 2002 961: 323-330. [Full Text]  

DAVID M. HARLAN
Islet Cell Allotransplantation as a Model System for a Bioengineering Approach to Reparative Medicine: Immunological Concerns
Ann NY Acad Sci 2002 961: 331-334. [Full Text]  

DENNIS W. METZGER
Immune Responses to Tissue-Engineered Extracellular Matrix Used as a Bioscaffold
Ann NY Acad Sci 2002 961: 335-336. [Full Text]  

CHRISTOPHER L. KARP, RICHARD WENSTRUP, and DAVID L. BUTLER
Immunological Barriers (Opportunities?) to the Use of Bioengineered Tissue: Taking Note of the Innate Immune System
Ann NY Acad Sci 2002 961: 337-340. [Full Text]  

POLLY MATZINGER
An Innate Sense of Danger
Ann NY Acad Sci 2002 961: 341-342. [Full Text]  

DAVID H. MUNN
Tolerogenic Antigen-Presenting Cells
Ann NY Acad Sci 2002 961: 343-345. [Full Text]  

RICHARD M. RANSOHOFF
Chemokines in Neurological Trauma Models
Ann NY Acad Sci 2002 961: 346-349. [Full Text]  

DAVID M. HARLAN, DENNIS W. METZGER, CHRISTOPHER L. KARP, POLLY MATZINGER, DAVID H. MUNN, RICHARD M. RANSOHOFF, and DENNIS W. METZGER
Immune Response to Engineered Tissues and Cells: Breakout Session Summary
Ann NY Acad Sci 2002 961: 350-351. [Full Text]  

ANDRÉ A. NEVES, NICK MEDCALF, and KEVIN M. BRINDLE
Tissue Engineering of Meniscal Cartilage Using Perfusion Culture
Ann NY Acad Sci 2002 961: 352-355. [Full Text]  

M. C. RITZ, R. GALLEGOS, M. B. CANHAM, M. ESKALAI, and F. R. GEORGE
PROVANT® Wound-Closure System Accelerates Closure of Pressure Wounds in a Randomized, Double-Blind, Placebo-Controlled Trial
Ann NY Acad Sci 2002 961: 356-359. [Full Text]  

JULIA E. BABENSEE, MELISSA M. STEIN, and LEAH K. MOORE
Interconnections between Inflammatory and Immune Responses in Tissue Engineering
Ann NY Acad Sci 2002 961: 360-363. [Full Text]  

ANDREAS KERN, KANG LIU, and JONATHAN MANSBRIDGE
Modulation of Interferon-Gamma Response by Dermal Fibroblast Extracellular Matrix
Ann NY Acad Sci 2002 961: 364-367. [Full Text]  

RAYMOND E. SICARD
Differential Inflammatory and Immunological Responses in Tissue Regeneration and Repair
Ann NY Acad Sci 2002 961: 368-371. [Abstract] [Full Text]  

GAIL K. NAUGHTON
From Lab Bench to Market: Critical Issues in Tissue Engineering
Ann NY Acad Sci 2002 961: 372-385. [Abstract] [Full Text]  

ROBERT NEREM, HELENE SAGE, CHRISTINE A. KELLEY, and LORÉ ANNE McNICOLD
Symposium Summary
Ann NY Acad Sci 2002 961: 386-389. [Full Text]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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